Keiichi Kuwano

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

Keiichi Kuwano, Asami Hashino, Tetsuo Asaki et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 160 citations

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 87 citations

Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

Tetsuo Asaki, Keiichi Kuwano, Keith Morrison et al. · Journal of Medicinal Chemistry · 2015 · 86 citations

Hypertension, Cardiovascular Pharmacology, Pharmacotherapy +21

Structure–activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists

Tetsuo Asaki, Taisuke Hamamoto, Yukiteru Sugiyama et al. · Bioorganic & Medicinal Chemistry · 2007 · 50 citations

Prostacyclin Receptor Agonists, Molecular Pharmacology, Diphenylpyrazine Derivatives +10

A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries

Chiaki Fuchikami, Kohji Murakami, Koyuki Tajima et al. · European Journal of Pharmacology · 2016 · 18 citations

Medicinal Chemistry, Vasodilation Mode, Medicine +10