The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis

Takeshi Itoh, Hidetoshi Matsuda, Masatoshi Tanioka, +3

The Journal of Immunology

ImmunologyPathologyMatrix Metalloproteinase-2Musculoskeletal ResearchInflammatory Arthritis +19

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

Keiichi Kuwano, Asami Hashino, Tetsuo Asaki, +4

Journal of Pharmacology and Experimental Therapeutics

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda, +2

Journal of Pharmacology and Experimental Therapeutics

Crucial Role of Group IIA Phospholipase A ₂ in Oleic Acid–Induced Acute Lung Injury in Rabbits

S. Furue, Kenji Kuwabara, Katsuya Mikawa, +10

American Journal of Respiratory and Critical Care Medicine

Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: Correlation with lung surfactant protection

S. Furue, Katsuya Mikawa, Kahoru Nishina, +10

Critical Care Medicine

Structure–activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists

Tetsuo Asaki, Taisuke Hamamoto, Yukiteru Sugiyama, +2

Bioorganic & Medicinal Chemistry

Prostacyclin Receptor AgonistsMolecular PharmacologyDiphenylpyrazine DerivativesDerivativesStructure–activity Studies +8

Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of Eviprostat®, a phytotherapeutic agent for benign prostatic hyperplasia

Michiko Oka, Masaki Tachibana, Kumiko Noda, +3

Phytomedicine

Medicinal ChemistryUrologyOxysterolMedicineLipid Peroxidation +7

Galactose-Modified Cationic Liposomes as a Liver-Targeting Delivery System for Small Interfering RNA

Satoru Sonoke, Toshihiro Ueda, Kae Fujiwara, +2

Biological and Pharmaceutical Bulletin

NanotherapeuticsGlycobiologyGalactose-modified Cationic LiposomeGene DeliveryNanomedicine +22

Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels

Kenji Kuwabara, Koichi Shudo, Yozo Hori

FEBS Letters

ImmunologyPsoriatic ArthritisInflammatory ArthritisInflammationRheumatoid Disorder +15

Effects of the second-generation leukotriene B4 receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice

Kenji Kuwabara, Kiyoshi Yasui, Hirokuni Jyoyama, +3

European Journal of Pharmacology

InflammationRheumatologyRheumatoid DisorderAnti-inflammatoryAutoimmune Disease +10