Design, synthesis and biological evaluation of novel glucokinase activators

Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura et al. · Structure · 2004 · 503 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Alexander M. Efanov, David G. Barrett, Martin Brenner et al. · Endocrinology · 2005 · 132 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Glucokinase and glucose homeostasis: proven concepts and new ideas

Dorothy Zelent, Hadi Najafi, Stella Odili et al. · Biochemical Society Transactions · 2005 · 86 citations

Life Sciences, Biochemistry, Endocrinology +17

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 85 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +6

Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators

Tomoharu Iino, Daisuke Tsukahara, Kenji Kamata et al. · Bioorganic & Medicinal Chemistry · 2009 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14