Concepedia

Effect of Reversal of Neuromuscular Blockade with Sugammadex versus Usual Care on Bleeding Risk in a Randomized Study of Surgical Patients

Niels Rahe‐Meyer, Hein Fennema, Sam Schulman, Walter Klimscha, Michael Przemeck, Manfred Blobner, Hinnerk Wulf, Marcel Speek, Christine McCrary Sisk, Debora Williams‐Herman,

Anesthesiology · 2014 · 75 citations · 15 references

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Abstract

Sugammadex produced limited, transient (<1 h) increases in activated partial thromboplastin time and prothrombin time but was not associated with increased risk of bleeding versus usual care.

References

15

Prediction of Creatinine Clearance from Serum Creatinine

Donald W. Cockcroft, Henry Gault · Nephron · 1976 · 15.3K citations

Second symposium on the definition and management of anaphylaxis: Summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium

Hugh A. Sampson, Anne Muñoz‐Furlong, Ronna L. Campbell et al. · Journal of Allergy and Clinical Immunology · 2006 · 2.3K citations

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 451 citations

Reversal of Rocuronium-induced Neuromuscular Block by the Selective Relaxant Binding Agent Sugammadex

Iben Foss Sorgenfrei, K. Norrild, Per Larsen et al. · Anesthesiology · 2006 · 339 citations

Sugammadex Reversal of Rocuronium-Induced Neuromuscular Blockade: A Comparison with Neostigmine???Glycopyrrolate and Edrophonium???Atropine

Özlem Saçan, Paul F. White, Burcu Tufanogullari et al. · Anesthesia & Analgesia · 2007 · 237 citations