A. Bom

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide:  Synthesis and Structure−Activity Relationships

Julia M. Adam, David Jonathan Bennett, A. Bom et al. · Journal of Medicinal Chemistry · 2002 · 233 citations

Medicine, Medicinal Chemistry, Pharmacology +15

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Medicine, Neuroscience, Pharmacology +10

Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey

Hans D. de Boer, J. van Egmond, F. van de Pol et al. · British Journal of Anaesthesia · 2006 · 152 citations · Full text

Medicine, Neurology, Veterinary Anesthesiology +12

Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970

Ola Epemolu, A. Bom, F. Hope et al. · Anesthesiology · 2003 · 149 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14