Ken Cameron

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 451 citations

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Neuromodulation Therapies, Pharmacotherapy, Biomedical Engineering +22

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

Stuart Francis, Daniel R. Croft, Alexander W. Schüttelkopf et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 44 citations · Full text

Mutual induced fit in cyclodextrin–rocuronium complexes

Alan Cooper, Margaret Nutley, E.J. MacLean et al. · Organic & Biomolecular Chemistry · 2005 · 30 citations

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure–activity relationships of a series of isoxazoles

Paul Ratcliffe, Lynn Abernethy, Nasrin Ansari et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 19 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11