E.J. MacLean

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Medicine, Neuroscience, Pharmacology +10

Nanosized Polymetallic Resorcinarene-Based Host Assemblies that Strongly Bind Fullerenes

Ori D. Fox, James Cookson, Emma J. S. Wilkinson et al. · Journal of the American Chemical Society · 2006 · 84 citations

Natural Sciences, Chemistry, Materials Science +17

Effect of Included Solvent Molecules on the Physical Properties of the Paramagnetic Charge Transfer Salts β‘ ‘-(bedt-ttf)₄[(H₃O)Fe(C₂O₄)₃]·Solvent (bedt-ttf = Bis(ethylenedithio)tetrathiafulvalene)

Scott S. Turner, Peter Day, K. M. Abdul Malik et al. · Inorganic Chemistry · 1999 · 83 citations

Natural Sciences, Chemistry, Materials Science +17

Aggregation of [Cu${{\bf }{{{\bf II}\hfill \atop \bf 4\hfill}}}$] Building Blocks into [Cu${{\bf }{{{\bf II}\hfill \atop \bf 8\hfill}}}$] Clusters or a [Cu${{\bf }{{{\bf II}\hfill \atop \bf 4\hfill}}}$]_∞ Chain through Subtle Chemical Control

Joan Ribas, Patrick Gámez, Olivier Roubeau et al. · Chemistry - A European Journal · 2004 · 74 citations

Natural Sciences, Chemistry, Crystal Structure +16