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Prediction of Creatinine Clearance from Serum Creatinine
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1976
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Factors for age and body weight must be included for reasonable prediction. The authors derived a formula linking age and weight to creatinine clearance from data on 249 patients, then compared its predictions with four other methods against 24‑hour clearance measurements in 236 patients. The new formula, which reduces female values by 15%, achieved a correlation of 0.83 with measured clearances and produced differences no larger than those seen between paired 24‑hour measurements.
A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: Ccr = (140 – age) (wt kg)/72 × Scr(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.