Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Anna K. Clark, Ping K. Yip, John Grist et al. · Proceedings of the National Academy of Sciences · 2007 · 481 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Alignment/Phylogeny of the Papain Superfamily of Cysteine Proteases

Paul J. Berti, Andrew C. Storer · Journal of Molecular Biology · 1995 · 392 citations

Life Sciences, Biochemistry, Molecular Biology +14

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

S. Aubrey Stoch, Stefan Zajic, Julie A. Stone et al. · Clinical Pharmacology & Therapeutics · 2009 · 156 citations

Medicine, Pharmacology, Pharmacotherapy +17

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

George B. Stroup, Michael W. Lark, Daniel F. Veber et al. · Journal of Bone and Mineral Research · 2001 · 153 citations

Medicine, Biochemistry, Pharmacology +17

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

Renata M. Oballa, Jean‐François Truchon, Christopher I. Bayly et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 147 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6