Jean‐François Truchon

Evaluating Virtual Screening Methods:  Good and Bad Metrics for the “Early Recognition” Problem

Jean‐François Truchon, Christopher I. Bayly · Journal of Chemical Information and Modeling · 2007 · 835 citations

Ranking Algorithm, Engineering, Machine Learning +20

Comparison of Topological, Shape, and Docking Methods in Virtual Screening

Georgia B. McGaughey, Robert P. Sheridan, Christopher I. Bayly et al. · Journal of Chemical Information and Modeling · 2007 · 415 citations

Drug Target, Hit Identification, Virtual Screening Methods +19

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

Renata M. Oballa, Jean‐François Truchon, Christopher I. Bayly et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 147 citations

Chemical Engineering, Engineering, Applicable Method +7

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bernard Côté, Jason D. Burch, Ernest Asante‐Appiah et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 97 citations

Medicine, Antiviral Drug Development, Antiviral Therapy +11

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306

Janek Szychowski, Robert Papp, Evelyne Dietrich et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text