A novel method to load topotecan into liposomes driven by a transmembrane NH4EDTA gradient

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

Robert Hertzberg, Mary Jo Caranfa, Sidney M. Hecht · Biochemistry · 1989 · 551 citations

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 462 citations

Engineering, Biotransformation, Biochemistry +9

Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.

Alberto Gabizón, Amir Dagan, Dorit Goren et al. · PubMed · 1982 · 262 citations

Antitumor Activity, Cellular Pharmacology, Vivo Carriers +19

Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial?

Ruey Long Hong, Chang Huang, Yun Long Tseng et al. · PubMed · 1999 · 227 citations

Lipid Preparation, Nanomedicine, Polyethylene Glycol Coating +12