Concepedia

Non-Peptidic inhibitors of human chymase. Synthesis, structure–activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones

Fumihiko Akahoshi, Atsuyuki Ashimori, Takuya Yoshimura, Teruaki Imada, Masahide Nakajima, Naoko Mitsutomi, Shigeki Kuwahara, Tatsuyuki Ohtsuka, Chikara Fukaya, Mizuo Miyazaki,

Bioorganic & Medicinal Chemistry · 2001 · 14 citations · 37 references

DOI

Concepts

References

37

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

H Urata, Ayaka Kinoshita, K S Misono et al. · Journal of Biological Chemistry · 1990 · 880 citations · Full text

, , +11

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

Hitoshi Mizutani, Norman M. Schechter, Gerald S. Lazarus et al. · The Journal of Experimental Medicine · 1991 · 320 citations · Full text

, , +16

Increased Chymase-Dependent Angiotensin II Formation in Human Atherosclerotic Aorta

Makoto Ihara, Hidenori Urata, Akio Kinoshita et al. · Hypertension · 1999 · 200 citations · Full text

, , +12

Irreversible inhibition of serine proteases by peptide derivatives of (.alpha.-aminoalkyl)phosphonate diphenyl esters

Józef Oleksyszyn, James C. Powers · Biochemistry · 1991 · 198 citations

, , +15

Chymase cleavage of stem cell factor yields a bioactive, soluble product

B. Jack Longley, Lynda Tyrrell, Yongsheng Ma et al. · Proceedings of the National Academy of Sciences · 1997 · 185 citations

, , +15