Fumihiko Akahoshi

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

Mika Nabeno, Fumihiko Akahoshi, Hiroyuki Kishida et al. · Biochemical and Biophysical Research Communications · 2013 · 297 citations

Drug Target, Biochemistry, Medicine +9

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 148 citations · Full text

Biochemistry, Medicine, Rational Drug Design +7

Synthesis and Pharmacological Activity of Triazole Derivatives Inhibiting Eosinophilia

Youichiro Naito, Fumihiko Akahoshi, Shinji Takeda et al. · Journal of Medicinal Chemistry · 1996 · 144 citations

Asthma, Medicinal Chemistry, Allergy +14

Synthesis, Structure−Activity Relationships, and Pharmacokinetic Profiles of Nonpeptidic Difluoromethylene Ketones as Novel Inhibitors of Human Chymase

Fumihiko Akahoshi, Atsuyuki Ashimori, Hiroshi Sakashita et al. · Journal of Medicinal Chemistry · 2001 · 38 citations · Full text

Medicinal Chemistry, Nonpeptidic Difluoromethylene Ketones, Pharmaceutical Science +15

Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 36 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +11