Hiroyuki Kishida

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

Mika Nabeno, Fumihiko Akahoshi, Hiroyuki Kishida et al. · Biochemical and Biophysical Research Communications · 2013 · 297 citations

Drug Target, Biochemistry, Medicine +9

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 148 citations · Full text

Biochemistry, Medicine, Rational Drug Design +7

Crystal Structure of Penicillin Binding Protein 4 (dacB) from <i>Escherichia coli</i>, both in the Native Form and Covalently Linked to Various Antibiotics

Hiroyuki Kishida, Satoru Unzai, David I. Roper et al. · Biochemistry · 2005 · 93 citations

Crystal Structure, Protein Assembly, Biochemistry +13

Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter

Masahiro Hiraizumi, Tomoya Akashi, Kouta Murasaki et al. · Nature Structural & Molecular Biology · 2023 · 48 citations · Full text

Structure and catalytic mechanism of 2-<i>C</i>-methyl-<scp>D</scp>-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis

Hiroyuki Kishida, Takashi Wada, Satoru Unzai et al. · Acta Crystallographica Section D Biological Crystallography · 2002 · 36 citations

Isoprenoid Synthesis, Biosynthesis, Bioorganic Chemistry +14