The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

Thomas Kronbach, Daniel Mathys, Josef Gut et al. · Analytical Biochemistry · 1987 · 262 citations

Medicine, Biochemistry, Pharmacology +17

Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6

Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne et al. · Journal of Medicinal Chemistry · 1999 · 160 citations

Medicine, Biochemistry, Pharmacology +17

The Decreased in Vivo Clearance of CYP2D6 Substrates by CYP2D6*10 Might Be Caused Not Only by the Low-Expression but Also by Low Affinity of CYP2D6

Tsuyoshi Fukuda, Yuko Nishida, Susumu Imaoka et al. · Archives of Biochemistry and Biophysics · 2000 · 82 citations

Medicine, Pharmacokinetics, Pharmacology +12

The Integrated Use of Alternative Methods in Toxicological Risk Evaluation

Bas J. Blaauboer, Martin D. Barratt, J. Brian Houston · Alternatives to Laboratory Animals · 1999 · 52 citations

Pharmacy, Toxicology, Environmental Toxicology +10

The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status

Sandra Coecke, Vera Rogiers, Martin K. Bayliss et al. · Alternatives to Laboratory Animals · 1999 · 49 citations

Medicine, Biochemistry, Pharmacology +17