Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Su-Ju Lin, Pierre‐Antoine Defossez, Leonard Guarente · Science · 2000 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +17

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

David Sinclair, Leonard Guarente · Cell · 1997 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Matt Kaeberlein, Ryan Powers, Kristan K. Steffen et al. · Science · 2005 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +17

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis et al. · Nature · 2002 · 1.1K citations

Life Sciences, Biology, Physiology +14