Concepedia

Mitochondrial Dysfunction In Aging

Mitochondrial Dysfunction in Aging is a theoretical construct within the field of biogerontology that specifically characterizes the progressive decline in mitochondrial bioenergetic efficiency, increased reactive oxygen species production, and impaired mitochondrial dynamics and quality control that accumulate with age and contribute to cellular senescence and age-related pathologies.

1.6K

Publications

144.1K

Citations

8.5K

Authors

1.9K

Institutions

Publications per year

2017–2026

575

Parents

Publications

1.6K

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

, , +12

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

Kitt Falk Petersen, Douglas E. Befroy, Sylvie Dufour et al. · Science · 2003 · 2.1K citations · Full text

, , +17

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

Samuel E. Schriner, Nancy J. Linford, George M. Martin et al. · Science · 2005 · 1.7K citations

, , +17

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes, Nathan L. Price, Alvin J. Y. Ling et al. · Cell · 2013 · 1.5K citations · Full text

, , +12

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

Douglas C. Wallace · Science · 1992 · 1.3K citations

, , +17

1–5 of 1.6K

Authors

8.5K

  1. DM
    Douglass M. Turnbull

    Newcastle University, United Kingdom

    21 publications · 1.8K citations

    19

    h-index

  2. CL
    Christiaan Leeuwenburgh

    University of Florida, United States

    18 publications · 1.8K citations

    18

    h-index

  3. HV
    Holly Van Remmen

    The University of Texas at San Antonio Health Science Center, United States

    18 publications · 3.7K citations

    18

    h-index

  4. GP
    Gunter P. Eckert

    Goethe University Frankfurt, Germany

    17 publications · 1K citations

    16

    h-index

  5. RP
    Reinald Pamplona

    Universitat de Lleida, Spain

    16 publications · 1.6K citations

    16

    h-index

1–5 of 8.5K

Institutions

1.9K

  1. Newcastle University

    Newcastle upon Tyne, United Kingdom

    35 h-index

    223 publications

    41.9K citations

  2. National Institutes of Health

    Bethesda, United States

    30 h-index

    144 publications

    17.2K citations

  3. University of Washington

    Seattle, United States

    27 h-index

    219 publications

    39.2K citations

  4. National Institute on Aging

    Baltimore, United States

    27 h-index

    133 publications

    15.2K citations

  5. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    26 h-index

    166 publications

    16.1K citations

  6. Goethe University Frankfurt

    Frankfurt am Main, Germany

    26 h-index

    157 publications

    18K citations

  7. Harvard University

    Cambridge, United States

    26 h-index

    71 publications

    29.9K citations

  8. University of Wisconsin–Madison

    Madison, United States

    22 h-index

    83 publications

    9.4K citations

1–8 of 1.9K

Venues

  1. Aging Cell

    66 publications · 6K citations

    44

    h-index

  2. Mechanisms of Ageing and Development

    73 publications · 5.4K citations

    38

    h-index

  3. Experimental Gerontology

    62 publications · 3.6K citations

    37

    h-index

  4. Aging

    55 publications · 4.4K citations

    36

    h-index

  5. Free Radical Biology and Medicine

    37 publications · 3.9K citations

    34

    h-index

1–5