Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nancy E. Kohl, Charles A. Omer, Michael W. Conner et al. · Nature Medicine · 1995 · 539 citations

Medicine, Cancer Biology, Oncology +11

The facile dealkylation of phosphonic acid dialkyl esters by bromotrimethylsilane

Charles E. McKenna, Melvin T. Higa, Neil H. Cheung et al. · Tetrahedron Letters · 1977 · 445 citations

Natural Sciences, Chemistry, Organic Chemistry +5

Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

Hee-Won Park, Sobha R. Boduluri, John F. Moomaw et al. · Science · 1997 · 333 citations

Life Sciences, Biochemistry, Molecular Biology +17

Steady-state kinetic mechanism of ras farnesyl:protein transferase

David L. Pompliano, Elaine Rands, Michael D. Schaber et al. · Biochemistry · 1992 · 246 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +16

Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis

Daniel A. Pearson, Mary A. Blanchette, Mary Lou Baker et al. · Tetrahedron Letters · 1989 · 240 citations

Pharmacy, Medicinal Chemistry, Synthetic Medicinal Chemistry +8