3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Apoptosis, Immunology, Cell Death +4

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Marina Konopleva, Rooha Contractor, Twee Tsao et al. · Cancer Cell · 2006 · 1K citations · Full text

Hematological Malignancy, Medicine, Acute Myeloid Leukemia +11

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E. Czabotar, Erinna F. Lee, Mark F. van Delft et al. · Proceedings of the National Academy of Sciences · 2007 · 437 citations · Full text

Protein Assembly, Apoptosis, Molecular Biology +18

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Milan Bruncko, Thorsten Oost, Barbara Belli et al. · Journal of Medicinal Chemistry · 2007 · 294 citations · Full text

Immunology, Pharmacotherapy, Pharmaceutical Chemistry +19

Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins

Guoping Wang, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang et al. · Journal of Medicinal Chemistry · 2006 · 293 citations · Full text