Guiye Wu

3-Thiomorpholin-8-oxo-8<i>H</i>-acenaphtho[1,2-<i>b</i>]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure−Activity Relationship Studies

Zhichao Zhang, Guiye Wu, Feibo Xie et al. · Journal of Medicinal Chemistry · 2011 · 86 citations · Full text

Dual Inhibitor, Novel Dual Inhibitor, Chemical Biology +17

A novel BH3 mimetic S1 potently induces Bax/Bak‐dependent apoptosis by targeting both Bcl‐2 and Mcl‐1

Zhichao Zhang, Ting Song, Tiantai Zhang et al. · International Journal of Cancer · 2010 · 76 citations

Tumor Biology, Bh3 Mimetics, Bax/bak‐dependent Apoptosis +15

Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding

Zhichao Zhang, Jin Gao, Yuanyuan Wang et al. · Biochemical Pharmacology · 2009 · 39 citations

Rna Polymerase Ii, Medicine, Apoptosis +6

Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design

Zhichao Zhang, Hongna Yang, Guiye Wu et al. · European Journal of Medicinal Chemistry · 2011 · 33 citations · Full text

Bcl-2 Protein, Protein Function, Medicine +9

3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1

Ting Song, Xiangqian Li, Xilong Chang et al. · Bioorganic & Medicinal Chemistry · 2012 · 32 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +9