Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Lin‐Feng Chen, Stefano Monti, Przemysław Juszczyński et al. · Blood · 2007 · 311 citations

Life Sciences, Oncology, Pharmacology +16

Potent small molecule inhibitors of spleen tyrosine kinase (Syk)

Justine Lai, Paul J. Cox, Rajesh Patel et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 76 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro

Cherng-Jye Seow, Sung-Chian Chue, W.S. Fred Wong · European Journal of Pharmacology · 2002 · 66 citations

Medicine, Immunology, Pharmacology +13

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi, Ryo Naito, Akira Toyoshima et al. · Bioorganic & Medicinal Chemistry · 2005 · 54 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

The Non-Receptor-Associated Tyrosine Kinase Syk is a Regulator of Metastatic Behavior in Human Melanoma Cells

Christoph Höeller, Christiane Thallinger, Barbara Pratscher et al. · Journal of Investigative Dermatology · 2005 · 48 citations · Full text

Medicine, Cell Biology, Oncology +14