Akira Toyoshima

Synthesis and Antimuscarinic Properties of Quinuclidin-3-yl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate Derivatives as Novel Muscarinic Receptor Antagonists

Ryo Naito, Yasuhiro Yonetoku, Yoshinori Okamoto et al. · Journal of Medicinal Chemistry · 2005 · 151 citations · Full text

Molecular Pharmacology, Bladder Contraction, Antimuscarinic Properties +14

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi, Ryo Naito, Akira Toyoshima et al. · Bioorganic & Medicinal Chemistry · 2005 · 54 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +10

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides

Yasuhiro Yonetoku, Hirokazu Kubota, Yoshinori Okamoto et al. · Bioorganic & Medicinal Chemistry · 2006 · 38 citations

Channel Inhibitors, Medicinal Chemistry, Medicine +7

Synthesis of <i>C</i>-Ribo-nucleosides Having Typical Aromatic Heterocycles as Base Moiety

Masataka Yokoyama, Akira Toyoshima, Takahiro Akiba et al. · Chemistry Letters · 1994 · 27 citations

(+)-(<i>2R</i>,<i>5S</i>)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-<i>N</i>-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist

Isao Kinoyama, Nobuaki Taniguchi, Akira Toyoshima et al. · Journal of Medicinal Chemistry · 2005 · 21 citations · Full text