Synthesis and Antimuscarinic Properties of Quinuclidin-3-yl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate Derivatives as Novel Muscarinic Receptor Antagonists

Ryo Naito, Yasuhiro Yonetoku, Yoshinori Okamoto, +3

Journal of Medicinal Chemistry

Molecular PharmacologyBladder ContractionAntimuscarinic PropertiesDry MouthBiochemistry +12

PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells

Naoki Okashita, Yuichi Kumaki, Kuniaki Ebi, +10

Development

Epigenetic ChangeGeneticsMolecular BiologyEpigeneticsTranscriptional Regulation +18

Anti-breast cancer potential of daidzein in rodents

Xiaoping Liu, Naomi Suzuki, Y. R. Santosh Laxmi, +2

Life Sciences

Tumor BiologyBreast OncologyChemoprevention StrategyMedicinePharmacology +5

Combined Activation of Methyl Paraben by Light Irradiation and Esterase Metabolism toward Oxidative DNA Damage

Yoshinori Okamoto, Tomohiro Hayashi, Shinpei Matsunami, +1

Chemical Research in Toxicology

Dna DamageLight IrradiationOrganic ChemistryDermatologySunlight Irradiation +20

Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage

Kaoru Midorikawa, Takafumi Uchida, Yoshinori Okamoto, +6

Chemico-Biological Interactions

Dna DamageBiochemistryOncogenic AgentMetabolic ActivationToxicogenomics +8

<I>In-situ</I> X-ray Diffraction of Corrosion Products Formed on Iron Surfaces

Yohei Takahashi, Eiichiro Matsubara, Shigeru Suzuki, +5

MATERIALS TRANSACTIONS

Materials ScienceSodium ChlorideConventional X-ray SourceCorrosion TechnologyEngineering +11

A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis

Akira Aoki, Hirokazu Adachi, Yoko Mori, +6

The Journal of Toxicological Sciences

World Health OrganizationViral DiagnosticsImmunologyViral PathogenesisMolecular Biology +15

Peptide Based Interleukin-1.BETA. Converting Enzyme(ICE) Inhibitors: Synthesis, Structure Activity Relationships and Crystallographic Study of the ICE-inhibitor Complex.

Yoshinori Okamoto, Hideki Anan, Eiichi Nakai, +8

Chemical and Pharmaceutical Bulletin

DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry

Yoshinori Okamoto, Naoko Yoshida, Toru Suzuki, +6

Scientific Reports

Isoflavonoids with Antiestrogenic Activity from <i>Millettia </i><i>p</i><i>achycarpa</i>

Chihiro Ito, Masataka Itoigawa, Minako Kumagaya, +4

Journal of Natural Products

Furowanin BMedicinal ChemistryBioorganic ChemistryBotanyBiochemistry +10