Edmund Harrington

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 715 citations

Inflammation, Cell Autophagy, Signal Transduction +13

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock et al. · Journal of Medicinal Chemistry · 2015 · 87 citations

Immunology, Immunologic Mechanism, Janus Tyrosine Kinases +16

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

John P. Duffy, Edmund Harrington, Francesco G. Salituro et al. · ACS Medicinal Chemistry Letters · 2011 · 82 citations · Full text

Bile acid analogues are activators of pyrin inflammasome

Irina Alimov, Suchithra Menon, Nadire R. Cochran et al. · Journal of Biological Chemistry · 2019 · 59 citations · Full text

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy <i>in Vivo</i>

Ayako Honda, Edmund Harrington, Iván Cornella‐Taracido et al. · ACS Medicinal Chemistry Letters · 2015 · 51 citations · Full text

Mitophagy, Selective Inhibitors, Chemical Biology +21