Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel, +44

Nature Cell Biology

InflammationCell AutophagySignal TransductionHeme HomeostasisIron Metabolism +11

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock, +40

Journal of Medicinal Chemistry

ImmunologyImmunologic MechanismJanus Tyrosine KinasesCompound LibraryImmunotherapy +14

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

John P. Duffy, Edmund Harrington, Francesco G. Salituro, +18

ACS Medicinal Chemistry Letters

Bile acid analogues are activators of pyrin inflammasome

Irina Alimov, Suchithra Menon, Nadire R. Cochran, +14

Journal of Biological Chemistry

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy <i>in Vivo</i>

Ayako Honda, Edmund Harrington, Iván Cornella‐Taracido, +13

ACS Medicinal Chemistry Letters

MitophagySelective InhibitorsChemical BiologyMolecular PharmacologyMedicinal Chemistry +19

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

Jingrong Cao, Huai Gao, Guy W. Bemis, +9

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +8

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, +30

Blood Cancer Journal

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

David Estoppey, Jeffrey Hewett, Chantale T. Guy, +25

Scientific Reports

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

Carla Russo, Iván Cornella‐Taracido, Luisa Galli‐Stampino, +11

Blood

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

Luc J. Farmer, Guy W. Bemis, Shawn Britt, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNovel 4-Thiazolyl-2-phenylaminopyrimidinesMedicineNatural Sciences +11