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Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

Knockout MouseAllergyHumanized Rat AntibodyImmunologySelf-toleranceAntibody EngineeringAnti-rage TherapyAffinity MaturationImmunotherapyMedicine