Concepedia

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

William J.J. Finlay, Orla Cunningham, Matthew Lambert, Alfredo Darmanin-Sheehan, Xuemei Liu, Brian J. Fennell, Ciara M. Mahon, Emma Cummins, Jason Wade, Cliona O’Sullivan,

Journal of Molecular Biology · 2009 · 64 citations · 51 references

DOI

Concepts

References

51

RAGE Mediates a Novel Proinflammatory Axis

M. Hofmann, Steven Drury, Caifeng Fu et al. · Cell · 1999 · 1.9K citations · Full text

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Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Jong Sung Park, Daiva Svetkauskaite, Qianbin He et al. · Journal of Biological Chemistry · 2004 · 1.6K citations · Full text

, , +17

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

Michael P. Neeper, Ann Marie Schmidt, J Brett et al. · Journal of Biological Chemistry · 1992 · 1.5K citations · Full text

, , +10

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +13

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

Osamu Hori, J Brett, Timothy Slattery et al. · Journal of Biological Chemistry · 1995 · 1.1K citations · Full text

, , +7