Concepedia

Cdr Mutagenesis

CDR Mutagenesis is a targeted molecular engineering technique that introduces somatic hypermutations specifically within the complementarity-determining regions (CDRs) of antibody variable domains to enhance antigen-binding affinity during in vitro affinity maturation.

84

Publications

4.3K

Citations

504

Authors

145

Institutions

Publications per year

2017–2026

14

Variants

Complementarity-determining Region Mutagenesis

Parents

Publications

84

CDR Walking Mutagenesis for the Affinity Maturation of a Potent Human Anti-HIV-1 Antibody into the Picomolar Range

Wei-Ping Yang, Kimberly Green, Sally Pinz-Sweeney et al. · Journal of Molecular Biology · 1995 · 333 citations

, , +12

Residues that mediate DNA binding of autoimmune antibodies

Marko Radic, J J Mackle, Jan Erikson et al. · The Journal of Immunology · 1993 · 258 citations

, , +15

Thermodynamic analysis of an antibody functional epitope

Robert F. Kelley, Mark P. O'Connell · Biochemistry · 1993 · 169 citations

, , +17

A general method for greatly improving the affinity of antibodies by using combinatorial libraries

Arvind Rajpal, Nurten Beyaz, Lauric Haber et al. · Proceedings of the National Academy of Sciences · 2005 · 153 citations · Full text

, , +17

Two amino acid mutations in an anti-human CD3 single chain Fv antibody fragment that affect the yield on bacterial secretion but not the affinity

Sergey M. Kipriyanov, Gerhard Moldenhauer, Andrew C.R. Martin et al. · Protein Engineering Design and Selection · 1997 · 125 citations · Full text

, , +17

1–5 of 84

Authors

504

  1. PM
    Peter M. Tessier

    Rensselaer Polytechnic Institute, United States

    5 publications · 352 citations

    5

    h-index

  2. AC
    Andrew C.R. Martin

    University College London, United Kingdom

    3 publications · 156 citations

    3

    h-index

  3. MB
    Marvin B. Rittenberg

    Oregon Health & Science University, United States

    3 publications · 108 citations

    3

    h-index

  4. KT
    Kristiina Takkinen

    VTT Technical Research Centre of Finland, Finland

    3 publications · 124 citations

    3

    h-index

  5. TM
    Tim Manser

    Thomas Jefferson University, United States

    3 publications · 63 citations

    3

    h-index

1–5 of 504

Institutions

145

  1. Scripps Research Institute

    San Diego, United States

    9 h-index

    33 publications

    4.4K citations

  2. National Cancer Institute

    Bethesda, United States

    6 h-index

    25 publications

    969 citations

  3. National Institutes of Health

    Bethesda, United States

    6 h-index

    33 publications

    2.1K citations

  4. University College London

    London, United Kingdom

    5 h-index

    18 publications

    659 citations

  5. Oregon Health & Science University

    Portland, United States

    4 h-index

    18 publications

    485 citations

  6. Rensselaer Polytechnic Institute

    Troy, United States

    4 h-index

    17 publications

    1.3K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    3 publications

    129 citations

  8. Heidelberg University

    Heidelberg, Germany

    3 h-index

    9 publications

    625 citations

1–8 of 145

Venues

  1. The Journal of Immunology

    JI · 18 publications · 898 citations

    14

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 7 publications · 332 citations

    7

    h-index

  3. Journal of Biological Chemistry

    JBC · 6 publications · 399 citations

    6

    h-index

  4. Molecular Immunology

    5 publications · 214 citations

    5

    h-index

  5. Journal of Molecular Biology

    JMB · 5 publications · 546 citations

    5

    h-index

1–5