Dioxo-triazines as a novel series of cathepsin K inhibitors

Alignment/Phylogeny of the Papain Superfamily of Cysteine Proteases

Paul J. Berti, Andrew C. Storer · Journal of Molecular Biology · 1995 · 392 citations

Life Sciences, Biochemistry, Molecular Biology +14

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

S. Aubrey Stoch, Stefan Zajic, Julie A. Stone et al. · Clinical Pharmacology & Therapeutics · 2009 · 156 citations

Medicine, Pharmacology, Pharmacotherapy +17

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

George B. Stroup, Michael W. Lark, Daniel F. Veber et al. · Journal of Bone and Mineral Research · 2001 · 153 citations

Medicine, Biochemistry, Pharmacology +17

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis

Wu-Shiun Hou, Dieter Brömme, Yingming Zhao et al. · Journal of Clinical Investigation · 1999 · 153 citations · Full text

Life Sciences, Biochemistry, Genetics +17

A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys

Sanjay Kumar, Lauren Dare, Janice A. Vasko-Moser et al. · Bone · 2006 · 137 citations

Medicine, Endocrinology, Bone Metabolism +12