Concepedia

Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: Impacting hERG liability via aryl modifications

Mark D. McBriar, Henry Guzik, Sherry Shapiro, Ruo Xu, Jaroslava Paruchova, John W. Clader, Kim O’Neill, Brian E. Hawes, Steve Sorota, Michael Margulis,

Bioorganic & Medicinal Chemistry Letters · 2006 · 14 citations · 9 references

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Concepts

References

9

Mice lacking melanin-concentrating hormone are hypophagic and lean

Masako Shimada, Nicholas A. Tritos, Bradford B. Lowell et al. · Nature · 1998 · 1.2K citations

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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

David S. Ludwig, Nicholas A. Tritos, Jason Mastaitis et al. · Journal of Clinical Investigation · 2001 · 624 citations · Full text

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Chronic intracerebroventricular infusion of MCH causes obesity in mice

Akira Gomori, Akane Ishihara, Masahiko Ito et al. · American Journal of Physiology-Endocrinology and Metabolism · 2003 · 214 citations

, , +14

Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

Odile Della‐Zuana, Françoise Presse, Christine Ortola et al. · International Journal of Obesity · 2002 · 197 citations

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Characterization of a hERG Screen Using the IonWorks HT: Comparison to a hERG Rubidium Efflux Screen

Steve Sorota, Xue‐Song Zhang, Michael Margulis et al. · Assay and Drug Development Technologies · 2005 · 76 citations

, , +14