The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment

Amos B. Smith, Victoria A. Doughty, Qiyan Lin, +7

Angewandte Chemie International Edition

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2

Amos B. Smith, Qiyan Lin, Victoria A. Doughty, +6

Angewandte Chemie International Edition

Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists:  Orally Efficacious Antiobesity Therapeutics

Mark D. McBriar, Henry Guzik, Ruo Xu, +10

Journal of Medicinal Chemistry

ObesityMetabolic SyndromeEnergy HomeostasisMch ReceptorFunctional Selectivity +12

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

Timothy J. Kowalski, Brian D. Spar, Blair Weig, +11

European Journal of Pharmacology

ObesityNutritionMetabolic SyndromeEnergy HomeostasisMedicine +9

Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas

Mark D. McBriar, Henry Guzik, Sherry Shapiro, +14

Journal of Medicinal Chemistry

Spongistatin synthetic studies. 1. Construction of a C(29–48) subtarget

Amos B. Smith, Linghang Zhuang, Christopher S. Brook, +7

Tetrahedron Letters

Medicinal ChemistrySpongistatin Synthetic StudiesBioorganic ChemistryMacromolecular EngineeringUnprecedented Antitumor Activity +12

Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

Anandan Palani, Sherry Shapiro, Mark D. McBriar, +11

Journal of Medicinal Chemistry

Biaryl UreasFood IntakePharmacotherapyOral EfficacyExperimental Pharmacology +14

Spongistatin synthetic studies. 3. Construction of the C(1–17) spiroketal

Amos B. Smith, Quyan Lin, Kiyoshi Nakayama, +6

Tetrahedron Letters

Combinatorial ChemistrySpongistatin Synthetic StudiesBioorganic ChemistryMacromolecular EngineeringBiochemistry +12

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

Mark D. McBriar, John W. Clader, Inhou Chu, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesCarbamate Replacements +7

Spongipyran synthetic studies. Total synthesis of (+)-spongistatin 2

Amos B. Smith, Qiyan Lin, Victoria A. Doughty, +11

Tetrahedron

Bioorganic ChemistryTotal SynthesisPharmacologySynthetic ChemistryNatural Product Synthesis