Turning enzymes ON with small molecules

The Sequence of the Human Genome

J. Craig Venter, Mark D. Adams, Eugene W. Myers et al. · Science · 2001 · 13.7K citations

Life Sciences, Genetics, Molecular Genetics +11

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.8K citations

Education, Genetics, Molecular Biology +12

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

Haim Cohen, Christine Miller, Kevin J. Bitterman et al. · Science · 2004 · 1.9K citations

Life Sciences, Cell Biology, Molecular Biology +16

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Su-Ju Lin, Pierre‐Antoine Defossez, Leonard Guarente · Science · 2000 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +17