Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target

Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

Life Sciences, Genetics, Molecular Biology +10

Yeast surface display for screening combinatorial polypeptide libraries

Eric T. Boder, K. Dane Wittrup · Nature Biotechnology · 1997 · 1.8K citations

Engineering, Biochemistry, Biotechnology +13

<i>In vitro</i> selection and evolution of functional proteins by using ribosome display

Jozef Hanes, Andreas Plückthun · Proceedings of the National Academy of Sciences · 1997 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Randomization of genes by PCR mutagenesis.

R C Cadwell, Gerald F. Joyce · Genome Research · 1992 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

Achim Knappik, Liming Ge, Annemarie Honegger et al. · Journal of Molecular Biology · 2000 · 735 citations

Pharmacy, Biotechnology, Molecular Biology +16