Estrogen regulates neprilysin activity in rat brain

Metabolic Regulation of Brain Aβ by Neprilysin

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Science · 2001 · 944 citations

Aging, Neurochemical Biomarkers, Amyloid Beta Peptide +19

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Nature Medicine · 2000 · 856 citations

Neurodegenerative Diseases, Synaptic Signaling, Degenerative Pathology +9

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 701 citations · Full text

Premature Death, Neurodegenerative Diseases, Enhanced Proteolysis +11

Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice

Robert A. Marr, Edward Rockenstein, Atish Mukherjee et al. · Journal of Neuroscience · 2003 · 384 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Transgenic Mouse Models +15

Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain

Nobuhisa Iwata, Hiroaki Mizukami, Keiro Shirotani et al. · Journal of Neuroscience · 2004 · 251 citations · Full text