Concepedia

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

Yasuhiro Uno, Akinori Matsushita, Mitsunori Shukuya, Yasuka Matsumoto, Norie Murayama, Hiroshi Yamazaki

Biochemical Pharmacology · 2014 · 34 citations · 19 references

DOI

Concepts

References

19

Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Hiroshi Yamazaki, Mami Nakamura, Tomoko Komatsu et al. · Protein Expression and Purification · 2002 · 233 citations

, , +17

Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans

Tsutomu Shimada, Mayumi Mimura, Kiyoshi Inoue et al. · Archives of Toxicology · 1997 · 173 citations

, , +15

Structural Characterization of Human Cytochrome P450 2C19

R. Leila Reynald, Stefaan Sansen, C.D. Stout et al. · Journal of Biological Chemistry · 2012 · 133 citations · Full text

, , +17

CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone

Yasuhiro Uno, Hideki Fujino, Go Kito et al. · Molecular Pharmacology · 2006 · 119 citations

, , +12

Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity

Gordon C. Ibeanu, Burhan I. Ghanayem, Patricia Linko et al. · Journal of Biological Chemistry · 1996 · 88 citations · Full text

, , +16