Concepedia

Metabolism Variability

Metabolism Variability is a pharmacokinetic phenomenon characterized by interindividual differences in the rate and extent of metabolic transformation of drugs, primarily due to genetic, environmental, or physiological factors affecting drug-metabolizing enzymes.

702

Publications

43.8K

Citations

3.4K

Authors

1.1K

Institutions

Publications per year

2017–2026

98

Parents

Children

Publications

702

Human metabolic individuality in biomedical and pharmaceutical research

Karsten Suhre, So–Youn Shin, Robert P. Mohney et al. · Nature · 2011 · 1.1K citations · Full text

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The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

S.M. de Morais, G. Wilkinson, Joyce Blaisdell et al. · Journal of Biological Chemistry · 1994 · 952 citations · Full text

, , +17

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

Christian Gieger, Ludwig Geistlinger, Elisabeth Altmaier et al. · PLoS Genetics · 2008 · 766 citations · Full text

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A genome-wide perspective of genetic variation in human metabolism

Thomas Illig, Christian Gieger, Guangju Zhai et al. · Nature Genetics · 2009 · 667 citations · Full text

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The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

Theresa H. Sullivan-Klose, Burhan I. Ghanayem, Douglas A. Bell et al. · Pharmacogenetics · 1996 · 587 citations

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1–5 of 702

Authors

3.4K

  1. NL
    Neal L. Benowitz

    University of California, San Francisco, United States

    13 publications · 1.3K citations

    13

    h-index

  2. RF
    Rachel F. Tyndale

    University of Toronto, Canada

    13 publications · 659 citations

    12

    h-index

  3. JK
    Jeremy K. Nicholson

    Imperial College London, United Kingdom

    10 publications · 1.1K citations

    10

    h-index

  4. WK
    W. Kalow

    University of Toronto, Canada

    9 publications · 1K citations

    9

    h-index

  5. EH
    Elaine Holmes

    Imperial College London, United Kingdom

    9 publications · 878 citations

    9

    h-index

1–5 of 3.4K

Institutions

1.1K

  1. University of Toronto

    Toronto, Canada

    22 h-index

    81 publications

    5K citations

  2. Imperial College London

    London, United Kingdom

    20 h-index

    77 publications

    7.1K citations

  3. Karolinska Institutet

    Stockholm, Sweden

    18 h-index

    80 publications

    9.3K citations

  4. University of California, San Francisco

    San Francisco, United States

    17 h-index

    54 publications

    3.2K citations

  5. University of Washington

    Seattle, United States

    16 h-index

    90 publications

    8.1K citations

  6. National Institutes of Health

    Bethesda, United States

    10 h-index

    38 publications

    7K citations

  7. Vanderbilt University

    Nashville, United States

    10 h-index

    56 publications

    10K citations

  8. Centre for Addiction and Mental Health

    Toronto, Canada

    10 h-index

    33 publications

    1.7K citations

1–8 of 1.1K

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 59 publications · 5K citations

    39

    h-index

  2. PubMed

    Repository · 53 publications · 2.4K citations

    30

    h-index

  3. Drug Metabolism and Disposition

    28 publications · 1.5K citations

    22

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 26 publications · 1.2K citations

    19

    h-index

  5. Pharmacogenetics

    18 publications · 2.4K citations

    18

    h-index

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