Concepedia

Intermediate Metabolizer Phenotype

Intermediate Metabolizer Phenotype is a pharmacogenetic phenotype characterized by reduced enzymatic activity resulting from heterozygous or functionally deficient allelic variants in drug-metabolizing enzyme genes, leading to intermediate drug metabolism rates compared to normal and poor metabolizers.

90

Publications

3.9K

Citations

642

Authors

287

Institutions

Publications per year

2017–2026

29

Parents

Publications

90

Effect of Genetic Differences in Omeprazole Metabolism on Cure Rates for <i>Helicobacter pylori</i> Infection and Peptic Ulcer

Takahisa Furuta · Annals of Internal Medicine · 1998 · 336 citations

, , +17

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6

Ulrich M. Zanger, Joachim E. Fischer, Sebastian Raimundo et al. · Pharmacogenetics · 2001 · 268 citations

, , +17

Cyp2d6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants—a pilot study

Tilman T. Rau · Clinical Pharmacology & Therapeutics · 2004 · 201 citations

, , +17

A novel intronic mutation, 2988G&gt;A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects*1

Sebastian Raimundo · Clinical Pharmacology & Therapeutics · 2004 · 163 citations

, , +17

Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans

Masatoshi Nakajima · Clinical Pharmacology & Therapeutics · 2000 · 120 citations · Full text

, , +14

1–5 of 90

Authors

642

  1. ME
    Michel Eichelbaum

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

    5 publications · 422 citations

    5

    h-index

  2. SR
    Sebastian Raimundo

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

    4 publications · 538 citations

    4

    h-index

  3. MS
    Matthias Schwab

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

    4 publications · 397 citations

    4

    h-index

  4. KE
    Karen E. Weck

    University of North Carolina at Chapel Hill, United States

    3 publications · 148 citations

    3

    h-index

  5. DW
    David W. Haas

    Vanderbilt University, United States

    3 publications · 154 citations

    3

    h-index

1–5 of 642

Institutions

287

  1. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    6 h-index

    27 publications

    3K citations

  2. Vanderbilt University

    Nashville, United States

    5 h-index

    6 publications

    342 citations

  3. Inserm

    Paris, France

    4 h-index

    27 publications

    908 citations

  4. Vanderbilt University Medical Center

    Nashville, United States

    3 h-index

    3 publications

    122 citations

  5. Aarhus University Hospital

    Aarhus, Denmark

    3 h-index

    7 publications

    227 citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    3 h-index

    20 publications

    942 citations

  7. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    14 publications

    615 citations

  8. Mayo Clinic in Florida

    Jacksonville, United States

    3 h-index

    12 publications

    296 citations

1–8 of 287

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 7 publications · 654 citations

    7

    h-index

  2. Pharmacogenomics

    6 publications · 205 citations

    6

    h-index

  3. Pharmacogenetics and Genomics

    5 publications · 192 citations

    5

    h-index

  4. Frontiers in Pharmacology

    4 publications · 81 citations

    4

    h-index

  5. The Journal of Clinical Pharmacology

    3 publications · 84 citations

    3

    h-index

1–5