Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy-trans-3′,4′-bridged nucleic acids

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh, Alexei A. Koshkin, Jesper Wengel et al. · Chemical Communications · 1998 · 762 citations

Thermal Stabilities, Nucleic Acid Chemistry, Natural Sciences +12

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sandra Freier · Nucleic Acids Research · 1997 · 678 citations · Full text

Dna, Bioorganic Chemistry, Engineering +20

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1997 · 594 citations

Enantioselective Synthesis, Engineering, -Endo Sugar Puckering +6

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 183 citations

2′-O,4′-c-ethylene-bridged Nucleic Acids, Nucleic Acid Chemistry, Antisense Drug +8

Enantioselective Total Synthesis of Epothilones A and B Using Multifunctional Asymmetric Catalysis

Daisuke Sawada, Motomu Kanai, Masakatsu Shibasaki · Journal of the American Chemical Society · 2000 · 133 citations

Cross-coupling Reaction, Engineering, Natural Sciences +14