Concepedia

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases

Aranapakam M. Venkatesan, Atul Agarwal, Takao Abé, Hideki Ushirogochi, Mihira Ado, Tsuyoshi Takasaki, Osvaldo dos Santos, Zhong Li, Gerry Francisco, Yang I Lin

Bioorganic & Medicinal Chemistry · 2007 · 66 citations · 29 references

DOI

Concepts

References

29

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

A. R. English, James A. Retsema, Arthur E. Girard et al. · Antimicrobial Agents and Chemotherapy · 1978 · 397 citations · Full text

, , +14

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

Karen Bush, C Macalintal, B A Rasmussen et al. · Antimicrobial Agents and Chemotherapy · 1993 · 273 citations · Full text

, , +16

Synthesis and .beta.-lactamase inhibitory properties of 2.beta.-[(1,2,3-triazol-1-yl)methyl]-2.alpha.-methylpenam-3.alpha.-carboxylic acid 1,1-dioxide and related triazolyl derivatives

Ronald G. Micetich, Samarendra N. Maiti, Paul Spevak et al. · Journal of Medicinal Chemistry · 1987 · 106 citations · Full text

, , +7

1,2,4-Triazoles. XIII. Derivatives of the s-Triazolo[1,5-a]pyridine Ring System<sup>1a</sup>

K. T. POTTS, H. R. Burton, Jnanabrata Bhattacharyya · The Journal of Organic Chemistry · 1966 · 103 citations

, , +9

Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors:  Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates

Aranapakam M. Venkatesan, Yansong Gu, Osvaldo dos Santos et al. · Journal of Medicinal Chemistry · 2004 · 79 citations · Full text

, , +16