Concepedia

Beta-lactamase Structure-function Relationships

Beta-Lactamase Structure-Function Relationships is a biochemical framework that elucidates how the three-dimensional architecture and mechanistic features of beta-lactamase enzymes determine their catalytic efficiency and substrate specificity in conferring bacterial resistance to beta-lactam antibiotics.

628

Publications

33.5K

Citations

2.2K

Authors

608

Institutions

Publications per year

2017–2026

103

Parents

Publications

628

The structure of β-lactamases

R P Ambler · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1980 · 1.8K citations

, , +12

Beta-lactamase database (BLDB) – structure and function

Thierry Naas, Saoussen Oueslati, Rémy A. Bonnin et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 686 citations · Full text

, , +15

Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

David E. Ehmann, Haris Jahić, Philip L. Ross et al. · Proceedings of the National Academy of Sciences · 2012 · 527 citations · Full text

, , +14

The 3‐D structure of a zinc metallo‐beta‐lactamase from Bacillus cereus reveals a new type of protein fold.

S. Parès, E. Duée, M. Galleni et al. · The EMBO Journal · 1995 · 457 citations · Full text

, , +12

β-Lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein–protein interactions

André Galarneau, Martin Primeau, Louis‐Éric Trudeau et al. · Nature Biotechnology · 2002 · 409 citations

, , +12

1–5 of 628

Authors

2.2K

  1. JF
    Jean‐Marie Frère

    University of Liège, Belgium

    30 publications · 2.4K citations

    24

    h-index

  2. TP
    Timothy Palzkill

    Baylor College of Medicine, United States

    26 publications · 1.1K citations

    20

    h-index

  3. RA
    Robert A. Bonomo

    Louis Stokes Cleveland VA Medical Center, United States

    24 publications · 1.1K citations

    20

    h-index

  4. BK
    Brian K. Shoichet

    University of California, San Francisco, United States

    19 publications · 1.4K citations

    19

    h-index

  5. SM
    Shahriar Mobashery

    University of Notre Dame, United States

    21 publications · 1.1K citations

    19

    h-index

1–5 of 2.2K

Institutions

608

  1. Centre National de la Recherche Scientifique

    Paris, France

    34 h-index

    174 publications

    14.8K citations

  2. University of Liège

    Liège, Belgium

    31 h-index

    241 publications

    17K citations

  3. University of Oxford

    Oxford, United Kingdom

    24 h-index

    169 publications

    11.7K citations

  4. University of Bristol

    Bristol, United Kingdom

    21 h-index

    91 publications

    5.1K citations

  5. Baylor College of Medicine

    Houston, United States

    20 h-index

    92 publications

    3.8K citations

  6. Case Western Reserve University

    Cleveland, United States

    18 h-index

    75 publications

    3.4K citations

  7. Louis Stokes Cleveland VA Medical Center

    Cleveland, United States

    18 h-index

    58 publications

    2.7K citations

  8. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    15 h-index

    45 publications

    5.6K citations

1–8 of 608

Venues

  1. Journal of Molecular Biology

    JMB · 44 publications · 3K citations

    33

    h-index

  2. Journal of Biological Chemistry

    JBC · 45 publications · 2.3K citations

    31

    h-index

  3. Biochemistry

    42 publications · 2.5K citations

    31

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 56 publications · 2K citations

    28

    h-index

  5. Journal of the American Chemical Society

    JACS · 26 publications · 1.6K citations

    24

    h-index

1–5