Concepedia

Somatic hypermutation targeting is influenced by location within the immunoglobulin V region

Reuma Magori Cohen, Steven H. Kleinstein, Yoram Louzoun

Molecular Immunology · 2011 · 27 citations · 33 references

Open access

Concepts

Life SciencesGeneticsMolecular BiologyImmunogeneticsMolecular ImmunologyAffinity MaturationAntigen Receptor Gene RearrangementImmunoglobulin DiversityImmunoglobulin FunctionImmunoglobulin Gene RearrangementSomatic HypermutationAntibody MaturationAntibody Variable Region DiversificationImmunoglobulin Gene DiversificationImmunoglobulin Heavy Chain RearrangementImmunoglobulin Variable Region Mutagenesis

References

33

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 94.5K citations

Life Sciences, Bioinformatics, Sequence Analysis +3

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

Life Sciences, Genetics, Molecular Biology +14

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy et al. · Cell · 2000 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

IMGT(R), the international ImMunoGeneTics information system(R)

Marie‐Paule Lefranc, Véronique Giudicelli, Chantal Ginestoux et al. · Nucleic Acids Research · 2008 · 1.1K citations · Full text

Life Sciences, Genetics, Immunology +14

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

Phuong Pham, Ronda Bransteitter, John Petruska et al. · Nature · 2003 · 660 citations

Life Sciences, Genetics, Molecular Biology +8