Evidence for Alterations in Circulating Low-Molecular-Weight Antioxidants and Increased Lipid Peroxidation in Smokers on Hemodialysis

Abstract

Our data suggest that cigarette smoking further increases plasma-circulating products of lipid peroxidation, which are already increased in nonsmoking hemodialysis patients as compared to matched healthy controls. The lower plasma levels of ascorbate in hemodialysis patients who smoke suggest that these patients may be more susceptible to oxidative tissue damage caused by smoking.