Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Life Sciences, Cell Biology, Pharmacology +10

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

Life Sciences, Molecular Biology, Oncology +17

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

Simone Fulda, Wolfgang Wick, Michael Weller et al. · Nature Medicine · 2002 · 741 citations

Life Sciences, Oncology, Pharmacology +14

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

Alexei Degterev, Alexey A. Lugovskoy, Michael H. Cardone et al. · Nature Cell Biology · 2001 · 547 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +11

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression

Simone Fulda, Éric Meyer, Klaus‐Michael Debatin · Oncogene · 2002 · 392 citations

Life Sciences, Cancer Biology, Cell Biology +14