Nature Chemical Biology · 2014 · 66 citations · 42 references
Life SciencesMolecular BiologyPharmacologyCell SignalingDrug DiscoverySignal TransductionCell Signaling NetworksDrug-target Interaction MappingHedgehog SignalingReceptor PharmacologyReceptor RegulationTargeted Cancer TherapyCanonical Hedgehog SignalingHedgehog MedicineHedgehog Pathway InhibitorsHedgehog Signaling InhibitionPharmacological Targeting Of Hedgehog SignalingSignal Transduction In Hedgehog PathwayTherapeutic Target Identification
42
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn, Carol Wicking, Peter G. Zaphiropoulos et al. · Cell · 1996 · 2K citations · Full text
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text
Activating Smoothened mutations in sporadic basal-cell carcinoma
Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh et al. · Nature · 1998 · 1.3K citations