Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

Jill M. Grenier, Lin Wang, Gulam A. Manji, +9

FEBS Letters

Flagellin Is the Major Proinflammatory Determinant of Enteropathogenic <i>Salmonella</i>

Hui Zeng, Adam Carlson, Yanwen Guo, +5

The Journal of Immunology

Microbial PathogensInnate Immune SystemImmunologyImmune RegulationEscherichia Coli +16

TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism

Yimin Yu, Hui Zeng, Sean Lyons, +4

American Journal of Physiology-Gastrointestinal and Liver Physiology

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39

Frédéric Bassilana, Adam Carlson, Jennifer DaSilva, +26

Nature Chemical Biology

Signal TransductionReceptor Gpr39Signaling PathwayG Protein-coupled ReceptorMedicine +8

Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists

Stefan Peukert, Richard L. Hughes, Jill Nunez, +13

ACS Medicinal Chemistry Letters

Human Gpr39 ReceptorDiabetes ManagementPharmaceutical ScienceBiochemistryFunctional Selectivity +12

Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates

Romas Kudirka, Robyn M. Barfield, Jesse M. McFarland, +6

ACS Medicinal Chemistry Letters

Drug TargetBioorganic ChemistryChemical BiologyMedicinal ChemistryAntibody Engineering +15

Pauci-Immune Glomerulonephritis in Individuals With Disease Associated With Levamisole-Adulterated Cocaine

Adam Carlson, Delphine S. Tuot, Kuang‐Yu Jen, +4

Medicine

Glomerular DiseaseGlomerulonephritisUrologyAutoimmune DiseaseAllergy +10

Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway

Stefan Peukert, Rishi K. Jain, Adrian Geisser, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyOrtho-biphenyl CarboxamidesBiochemistryMedicineMechanism Of Action +5

CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models

Penelope M. Drake, Adam Carlson, Jesse M. McFarland, +7

Molecular Cancer Therapeutics

Lipoxygenase pathway inhibition impairs the allograft response.

Michael Jordan, Adam Carlson, Rosemary A. Hoffman, +1

PubMed