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Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity—Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

Molecular PharmacologyNeurodegenerative DiseasesBiochemistryHsp90α/β Selective InhibitorsMedicineNatural SciencesPharmacologyRational Drug DesignMolecular BiologyConformational StudyProtein MisfoldingStructure-based DesignMolecular DockingMolecular ModelingDrug Discovery