Concepedia

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity—Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

Justin T. Ernst, Michael Liu, Harmon Zuccola, Kevin Beaumont, Amy Turnbull, Adam Kallel, Bryan W. Vought, Dean Stamos

Bioorganic & Medicinal Chemistry Letters · 2013 · 61 citations · 19 references

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19

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

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NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud et al. · Cancer Research · 2008 · 478 citations · Full text

, , +8

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Paul A. Brough, Wynne Aherne, Xavier Barril et al. · Journal of Medicinal Chemistry · 2007 · 445 citations · Full text

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The HSP90 family of genes in the human genome: Insights into their divergence and evolution

Bin Chen, William H. Piel, Liming Gui et al. · Genomics · 2005 · 382 citations

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Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones

D.E. Dollins, J.J. Warren, Robert M. Immormino et al. · Molecular Cell · 2007 · 286 citations · Full text

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