Concepedia

Structure-based Binding Mechanisms

Structure-Based Binding Mechanisms is a molecular recognition framework that explains ligand-target interactions through the preferential binding of pre-existing conformational states of a biomolecule, distinguished from induced fit by its reliance on structural ensembles accessible in the absence of ligand.

1.1K

Publications

57K

Citations

5.3K

Authors

1.3K

Institutions

Publications per year

2017–2026

239

Parents

Publications

1.1K

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Katjuša Brejc, Willem J. van Dijk, Remco V. Klaassen et al. · Nature · 2001 · 1.8K citations

, , +17

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

Jason E. Gestwicki, Christopher W. Cairo, Laura E. Strong et al. · Journal of the American Chemical Society · 2002 · 699 citations

, , +16

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

Gregory D. Van Duyne, Robert F. Standaert, P. Andrew Karplus et al. · Science · 1991 · 645 citations

, , +13

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Zhihong Liu, Chaohong Sun, Edward T. Olejniczak et al. · Nature · 2000 · 638 citations

, , +14

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

Martin Pfaff, Kirsten Tangemann, Beate Müller et al. · Journal of Biological Chemistry · 1994 · 534 citations · Full text

, , +17

1–5 of 1.1K

Authors

5.3K

  1. FH
    Fraser Hof

    University of Victoria, Canada

    7 publications · 258 citations

    7

    h-index

  2. FD
    François Diederich

    ETH Zurich, Switzerland

    6 publications · 514 citations

    6

    h-index

  3. DP
    David P. Lane

    University of Dundee, United Kingdom

    6 publications · 215 citations

    6

    h-index

  4. DE
    David E. Shaw

    D. E. Shaw Research, United States

    5 publications · 392 citations

    5

    h-index

  5. PM
    Peter M. Blumberg

    National Cancer Institute, United States

    5 publications · 91 citations

    5

    h-index

1–5 of 5.3K

Institutions

1.3K

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    153 publications

    5.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    61 publications

    5K citations

  3. Chinese Academy of Sciences

    Beijing, China

    20 h-index

    88 publications

    8.4K citations

  4. Columbia University

    New York, United States

    17 h-index

    43 publications

    2.3K citations

  5. National Institutes of Health

    Bethesda, United States

    14 h-index

    75 publications

    2.9K citations

  6. Harvard University

    Cambridge, United States

    14 h-index

    35 publications

    4K citations

  7. Scripps Research Institute

    San Diego, United States

    13 h-index

    54 publications

    2.6K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    13 h-index

    40 publications

    4.4K citations

1–8 of 1.3K

Venues

  1. Journal of the American Chemical Society

    JACS · 55 publications · 5K citations

    37

    h-index

  2. Journal of Molecular Biology

    JMB · 50 publications · 3.2K citations

    33

    h-index

  3. Biochemistry

    45 publications · 2.2K citations

    29

    h-index

  4. Journal of Biological Chemistry

    JBC · 40 publications · 2.6K citations

    29

    h-index

  5. Journal of Medicinal Chemistry

    54 publications · 2.6K citations

    27

    h-index

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