Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Loren Lasko, Clarissa G. Jakob, Rohinton Edalji, +36

Nature

Lineage-specific TumoursMedicineImmune Checkpoint InhibitorAnti-cancer AgentTumor Suppressor +6

Structural Basis for the Inhibition of Caspase-3 by XIAP

Stefan J. Riedl, Martin Renatus, Robert Schwarzenbacher, +5

Cell

Protein FunctionSignal TransductionG Protein-coupled ReceptorMedicineMechanism Of Action +5

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Zhihong Liu, Chaohong Sun, Edward T. Olejniczak, +6

Nature

BiochemistryNatural SciencesMolecular BiologyStructural BasisCrystallography +2

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Emily J. Faivre, Keith F. McDaniel, Daniel H. Albert, +31

Nature

Bd2 BromodomainMedicineNatural SciencesMolecular BiologyCancer Biology +7

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Thorsten Oost, Chaohong Sun, Robert C. Armstrong, +14

Journal of Medicinal Chemistry

ImmunologyCell DeathAntiapoptotic Protein XiapPharmacotherapyImmunotherapy +16

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Chaohong Sun, Mengli Cai, Angelo Gunasekera, +8

Nature

Nmr StructureApoptosisMolecular BiologyCell DeathMedicine

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP

Chaohong Sun, Mengli Cai, Robert Meadows, +5

Journal of Biological Chemistry

Species differences and molecular determinant of TRPA1 cold sensitivity

Jun Chen, Dawon Kang, Jing Xu, +6

Nature Communications

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin, +34

Nature Chemical Biology

Protein FunctionSignal TransductionMolecular RegulationPrc2 ComplexMolecular Biology +5

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP

Hua Zou, Ruomei Yang, Junshan Hao, +6

Journal of Biological Chemistry