Concepedia

Structure-based Protein Design

Structure-Based Protein Design is a computational protein engineering approach that belongs to the class of structure-guided design methods, distinguished by its reliance on the three-dimensional atomic structure of proteins to rationally design amino acid sequences that stabilize a desired conformation or function.

347

Publications

25.6K

Citations

2K

Authors

495

Institutions

Publications per year

2017–2026

114

Parents

Publications

347

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Brian Kuhlman, Gautam Dantas, Gregory C. Ireton et al. · Science · 2003 · 1.7K citations

, , +15

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

Ching‐Lin Hsieh, Jory A. Goldsmith, Jeffrey M. Schaub et al. · Science · 2020 · 1.4K citations · Full text

, , +17

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Jason S. McLellan, Man Chen, Michael Joyce et al. · Science · 2013 · 1.1K citations · Full text

, , +17

Computational design of receptor and sensor proteins with novel functions

Loren L. Looger, Mary A. Dwyer, James J. Smith et al. · Nature · 2003 · 667 citations

, , +16

Principles for designing ideal protein structures

Nobuyasu Koga, Rie Koga, Gaohua Liu et al. · Nature · 2012 · 593 citations · Full text

, , +12

1–5 of 347

Authors

2K

  1. DB
    David Baker

    University of Washington, United States

    22 publications · 4.6K citations

    21

    h-index

  2. BK
    Brian Kuhlman

    University of North Carolina at Chapel Hill, United States

    16 publications · 3.1K citations

    16

    h-index

  3. WF
    William F. DeGrado

    University of Pennsylvania, United States

    9 publications · 1.5K citations

    9

    h-index

  4. JS
    Jason S. McLellan

    The University of Texas at Austin, United States

    7 publications · 3.3K citations

    7

    h-index

  5. BS
    Barney S. Graham

    National Institute of Allergy and Infectious Diseases, United States

    6 publications · 1.6K citations

    6

    h-index

1–5 of 2K

Institutions

495

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    30 h-index

    75 publications

    19.1K citations

  2. University of Washington

    Seattle, United States

    26 h-index

    195 publications

    29.1K citations

  3. University of Pennsylvania

    Philadelphia, United States

    13 h-index

    49 publications

    4.5K citations

  4. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    12 h-index

    44 publications

    3.2K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    36 publications

    1.8K citations

  6. University of California, San Francisco

    San Francisco, United States

    10 h-index

    25 publications

    2.6K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    9 h-index

    26 publications

    2.1K citations

  8. California Institute of Technology

    Pasadena, United States

    9 h-index

    31 publications

    2.2K citations

1–8 of 495

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 22 publications · 3.1K citations

    22

    h-index

  2. Journal of Molecular Biology

    JMB · 21 publications · 1.6K citations

    20

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    18 publications · 669 citations

    16

    h-index

  4. Science

    14 publications · 6.4K citations

    14

    h-index

  5. Proteins Structure Function and Bioinformatics

    14 publications · 731 citations

    13

    h-index

1–5