Concepedia

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Sunny Abraham, Michael J. Hadd, Lan P. Tran, Troy Vickers, Janice A. Sindac, Zdravko V. Milanov, Mark W. Holladay, Shripad S. Bhagwat, Helen Hua, Julia M. Ford Pulido,

Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations · 9 references

DOIFull text

Open access

Concepts

References

9

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

, , +6

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

, , +4

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

Thomas H. Schindler, William G. Bornmann, Patricia Pellicena et al. · Science · 2000 · 1.8K citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 948 citations · Full text

, , +11

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena et al. · PubMed · 2002 · 940 citations

, , +18