Helen Hua

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Martin W. Rowbottom, Raffaella Faraoni, Qi Chao et al. · Journal of Medicinal Chemistry · 2011 · 58 citations · Full text

Orally Efficacious Inhibitor, Chemoprevention Strategy, Immunology +19

A mechanistic approach for predicting mass transfer in bioreactors

John A. Thomas, Xiaoming Liu, Brian DeVincentis et al. · Chemical Engineering Science · 2021 · 43 citations

Engineering, Mechanistic Approach, Biochemical Engineering +4

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Sunny Abraham, Michael J. Hadd, Lan P. Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations · Full text

Medicinal Chemistry, Pyrrolotriazine Analogs, Novel Series +11

Discovery of Highly Potent and Selective Pan-Aurora Kinase Inhibitors with Enhanced in Vivo Antitumor Therapeutic Index

Gang Liu, Sunny Abraham, Lan P. Tran et al. · Journal of Medicinal Chemistry · 2012 · 10 citations · Full text

Novel Therapy, Aurora A, Medicine +15

Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases

Gang Liu, Brian T. Campbell, Mark W. Holladay et al. · ACS Medicinal Chemistry Letters · 2012 · 10 citations · Full text

Pharmacotherapy, Globally Selective Inhibitor, Pharmaceutical Chemistry +27