ACS Medicinal Chemistry Letters · 2012 · 35 citations · 16 references
Biased AgonismMolecular PharmacologyMolecular PhysiologyBiochemistryG Protein-coupled ReceptorNatural PhenolsMedicineFunctional SelectivityReceptor (Biochemistry)Non-peptide LigandPharmacologyGpr35-active Natural PhenolsDrug Discovery
We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.
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